Results of the Minnesota randomized prospective trial of cyclosporine versus
Cyclosporine nephrotoxicity was detected in only 8
1016/s0270-9295(03)00090-1 Abstract After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem
The occurrence of epithelial vacuolization in clinical biopsy material suggests a direct toxic effect of tacrolimus and cyclosporine on the renal tubule
Cyclosporine represented a major advance in the medical management of patients with organ transplantation, but its use is limited by the frequent occurrence of
Cyclosporine Nephrotoxicity: Pathogenesis, Prophylaxis, Therapy, and Prognosis B
TLDR
Histological changes appear as obliterative vasculopathy of the afferent
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities can plague kidney transplant recipients
Kuroyanagi Y, Gotoh Y, Kasahara K, Nagano C, Fujita N, Yamakawa S, Yamamoto M, Takeda A, Uemura O
CsA nephrotoxicity is associated with tubulointerstitial injury progressing to nephropathy
Dieperink H, Starklint H, and Leyssac PP (1983)
Serial allograft biopsies were performed on a renal transplant patient who experienced recurrent episodes of acute cellular rejection as well as cyclosporine nephrotoxicity
After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem
H H Parving; H H Parving (NS) in the CsA and placebo groups, respectively
standard dose cyclosporine, or IL-2R Background: High dose of cyclosporine (CyA) for ≥2 years in children with steroid-dependent nephrotic syndrome (SDNS) increases the risk for nephropathy
Elevated serum CNI trough levels may help make the diagnosis, although CNI nephrotoxicity is not necessarily dose dependent
54, No
4 years
Controls received the vehicle only (olive oil)
27 In kidney allograft recipients, chronic CNI nephrotoxicity typically occurs several months posttransplantation and the incidence increases gradually with time, probably due to cumulative and persistent vascular
2009 Feb;4 (2):481-508