Preparation and Administration (2
EMEND for injection 150 mg on Day 1 as an intravenous infusion over 20 to 30 minutes
Manufacturer recommends decreasing starting dose of lurasidone to 20 mg/day and maximum daily dose of lurasidone 80 mg when coadministered with moderate CYP3A4
Emend is FDA approved for the use with other antiemetic (anti-nausea) agents for the prevention of acute or delayed nausea and vomiting caused by
The recommended dose of
The recommended dosage of EMEND for injection, dexamethasone, and a 5-HT 3 antagonist in adults for the prevention of nausea and vomiting associated with
The most common adverse
The recommended dosage of EMEND for injection, dexamethasone, and a 5-HT
6 mg/kg; however, only one patient received dosing expressed as mg/kg
antagonist in adults and pediatric patients 12 years of age and older who can swallow oral capsules, for the prevention Dosing of EMEND for oral suspension is based on weight, to a maximum of 125 mg on Day 1 and 80 mg on Days 2 and 3
Postdischarge nausea and vomiting (PDNV) refers to symptoms that occur after discharge for outpatient procedures
The dose of dexamethasone in chemotherapy induced nausea and vomiting (CINV) clinical trials was chosen to account for active substance interactions (see section 4
Administer dexamethasone 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 through 4
METHODS ASCO convened an Expert Panel and updated the systematic review
Race
Fosaprepitant is a single-dose medication that can be beneficial to the patient for as many as 72 hours after injection prior to emetogenic chemotherapy
, dexamethasone) is coadministered, patients should be given 50% of the recommended pediatric dose on Days 1 to 4
In the
1) receptor antagonists
3-Day Dosage Regimen for Use with Single- or Multi-Day Regimens of HEC or MEC: 6 months to less than 12 years: Day 1: 3 mg/kg IV over 60 minutes
150mg/vial; Oral suspension (aprepitant) Note: A 50% dosage reduction of dexamethasone on Days 3 and 4 is recommended to account for drug interaction with aprepitant; MEC (single-dose regimen) Day 1: 130 mg IV infused over 30 minutes or as IV push over 2 min; complete infusion or injection ~30 minutes before chemotherapy The recommended dosage of EMEND for injection, dexamethasone, and a 5-HT 3 antagonist for the prevention of nausea and vomiting associated with administration of HEC or MEC in adults is shown in Table 1 or Table 2, respectively
EMEND has not been studied for the treatment of established nausea and vomiting