This interaction was clinically relevant with electroclinical deterioration in 55% of patients
A clinical case series is presented to characterize the interaction between carbapenem antibiotics and sodium valproate
interaction, meropenem, valproic acid (VPA), therapeutic drug monitoring
Recent Abstract Valproic acid (VPA) is a widely used antiepileptic drug (AED)
Of the total drug interactions, 14 are major, 22 are moderate, and 1 is minor
Interactions between valproic acid and carbapenems
Carcas A
It is recommended that this combination should be avoided provided that a viable alternative is available
We observed rapid and clinically significant decreases in valproic acid levels after initiating meropenem in delayed meropenem treatment of valproic acid toxicity with fluoxetine and lamotrigine co-ingestion: a case report Previous Article WHEN THE BRAIN BLEEDS, AN UNUSUAL SUSPECT? Next Article WHEN TWO RARE CONDITIONS COLLIDE: HEPARIN-INDUCED THROMBOCYTOPENIA COMPLICATED BY "RIGHT-SIDED" MAY-THURNER SYNDROME PMID: 22435264 Abstract Valproic acid and meropenam is commonly co-administrated in neurosurgical patients
2009 Feb;70(2):193-4
This can cause loss of seizure control or changes in behavior
The pharmacological interaction between VPA and meropenem is characterized by a rapid decrease in VPA concentrations, which contraindicates concurrent use
Valproic acid (VPA) and derivatives are effective anticonvulsants and provide treatment options for numerous mood disorders [1]
This off-label usage of meropenem is based on the drug-drug interaction between carbapenems and valproic acid, which reduced the level of valproic acid within 24 h after The serum concentration of valproic acid (VPA) in epilepsy patients decreased by the administration of carbapenem antibiotics, such as meropenem, panipenem or imipenem, to a sub-therapeutic level
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Valproic acid (VPA) is a common interaction, meropenem, valproic acid (VPA), therapeutic drug monitoring
However, the cause for the change in VPA pharmacokinetics is unclear
Treatment with valproic acid 1000 mg as a continuous intravenous infusion over 24 Although the valproic acid dosage was increased, valproic acid levels did not return to the therapeutic range
Traditional treatment for VPA toxicity is primarily supportive care Valproic acid is widely used in the treatment of generalized tonic-clonic and partial seizures
This off-label usage of meropenem is based on the drug-drug interaction between carbapenems and valproic acid, which reduced the level of valproic acid within 24 hours Meropenem-valproic acid interaction in patients with cefepime-associated status epilepticus:54—8
Therefore, close monitoring of valproate levels is necessary when initiating a carbapenem antibiotic in patients Analysis of the valproic acid-meropenem interaction in hospitalised patients
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valproic acid will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism
Am J Emerg Med
The interaction between valproic acid and carbapenem antibiotics is well described and this interaction might be beneficial in the setting of toxic VPA ingestion
Does valproic acid interact with my other drugs? Enter other medications to view a detailed report
2011 Oct;113(8) :644-8
In comparison with expected population-kinetic based serum levels, we observed 90
We present a case of massive VPA overdose that was managed using a combination of The Ministry of Health and Welfare, Japan banned coadministration of carbapenems, such as panipenem/betamipron (PAPM), meropenem (MEPM), and valproic acid (VPA) because clinical reports have indicated that the coadministration caused seizures in epileptic patients due to lowered plasma levels of VPA
8 and 93
Case description: An intubated, unresponsive patient arrived via emergency medical services Drug interaction In a retrospective study, a patient [age and sex not stated ] experienced valproic acid level decreased [ duration of treatment to reaction onset and outcome not stated ] during concomitant therapy with meropenem and valproic acid [ dosages, routes and indications not stated ]
Two hypotheses attempt to explain the lower levels of valproic acid during meropenem co-administration(5,16)
Valproic Acid and Carbapenem Antibiotics Interaction
A series of studies have indicated that valproic acid (VPA) plasma concentration decreased rapidly when used concomitantly with carbapenem antibiotics
Introduction Valproic acid an antiepileptic drug is metabolized mainly by liver (cytochrome P450
The interaction between valproic acid and meropenem is serious, especially because of the dramatic decrease in the antiepileptic serum concentrations
Interactions between carbapenems and antiepileptics can have significant consequences on seizure control
Drug interactions are common, and the effects of these interactions can range from innocuous to deadly
interaction, meropenem, valproic acid (VPA), therapeutic drug monitoring
Concomitant administration of meropenem and valproic acid reportedly leads to a rapid decline in serum concentrations of valproic acid, which is sometimes associated with seizures
Use of meropenem to treat valproic acid overdose
Meropenem as
2007 Jan 1; 64 : 54-58 View in Article A total valproic acid level of 844 mg/L and an unbound valproic acid level of 604 mg/L were observed
Vélez Díaz-Pallarés et al 8 Seizure worsening caused by decreased serum valproate INTRODUCTION Meropenem (MER) is a carbapenem antibiotic used in The Netherlands in critically ill patients
A series of studies have indicated that valproic acid (VPA) plasma concentration decreased rapidly when used concomitantly with carbapenem antibiotics, including meropenem (MEPM)
Analysis of the valproic acid-meropenem interaction in hospitalised patients
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finerenone
(5
Because of valproic acid's toxicity, use in children younger than 2 years of age requires extreme caution
doi - This interaction is complex, persistent, and not resolved by valproate dose increases
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