Meropenem and valproic acid interaction

The combined use of valproic acid and a carbapenem is likely to occur in patients with central nervous system infections resulting from head trauma or surgical procedures; serious systemic infections, including pneumonia; and generalized seizure disorders. Valproic acid and meropenam is commonly co-administrated in neurosurgical patients

2024-03-28
    Paracetamol infusionslösung
  1. This can cause loss of seizure control or changes in behavior
  2. PMID: 16170544
  3. 03
  4. Front
  5. doi: 10
  6. 08
  7. doi: 10
  8. 1016/j
  9. 51-23
  10. 4 μg/mL on day 27
  11. doi: 10
  12. 73
  13. (7
  14. 1016/j
  15. 1
  16. meropenem decreases levels of valproic acid by unknown mechanism
  17. Applies to: Valproate Sodium (valproic acid) and meropenem
  18. Introduction: Valproic acid is a commonly used antiepileptic drug
  19. 2005 Sep;31 (9):1293-4
  20. 10
  21. The patient died on day 11
  22. 51-23
  23. doi: 10
  24. 2016 Oct;34(8):536-7
  25. Expand
  26. Pharmacokinetic interaction between valproic acid and meropenem
  27. Expand