Using gemfibrozil together with atorvastatin can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue
Brand name: Lopid
Drug information provided by: Merative, Micromedex US Brand Name Gemfibrozil is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the
Gemfibrozil is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and triglycerides (other fatty substances) in the blood in
Pravastatin and fluvastatin are the safest statins in this situation and can be considered for use with gemfibrozil if the benefit
HIV treatments called protease inhibitors such as saquinavir and ritonavir (Norvir)
Gemfibrozil Description
Gemfibrozil, one of the fibrates, but not fenofibrate, interferes with statin glucuronidation, which may increase the risk of myopathydue to elevations in statin
Fibric acid derivatives activate peroxisome proliferator activated receptor α (PPAR
Prescribed for High Cholesterol, High Cholesterol - Familial Heterozygous more
(See "Screening for lipid disorders in adults", section on 'Choice of tests' and "Atherosclerotic cardiovascular disease risk assessment for primary prevention in adults Fibrates can be prescribed with a statin, ezetimibe, or taken alone as a statin alternative
HIV treatments called protease inhibitors such as saquinavir and ritonavir (Norvir)
Gemfibrozil belongs to a group of drugs known as "fibrates
Gemfibrozil helps reduce cholesterol and triglycerides (fatty acids) in the blood
Statin dose ranges include low-, moderate-, and/or high-intensity LDL-C-lowering therapy, depending on specific statin
Fibric acid derivatives activate peroxisome proliferator activated receptor α (PPAR-α)
However
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If your provider prescribes both fibrates and statins, you’ll receive instructions about risks, benefits and side effects to watch for
Statin-gemfibrozil combination therapy is effective in reducing total cholesterol, LDL and triglycerides with a trend toward raising HDL in pts with hyperlipidemia resistant to either agent alone
Baseline and posttreatment body mass indexes, hemoglobin A 1c, and lipid