patients receiving atorvastatin had their dose titrated until they reached target LDL-C of < 2
The hazard ratio in the 1-3 years after starting treatment for women was 1
21 to Jan 1, 2018 · pravastatin 20mg produces an approximate LDL reduction of 24% - if the dose of pravastatin is doubled to 40mg then there is an approximate 30% LDL reduction expected with this dose of pravastatin; the "6 percent rule" holds approximately for all statins (1,2) Reference: J Am Coll Cardiol
reduction in plasma cholesterol and LDL (statins alter the balance of cholesterol and cholesteryl ester within the hepatocyte and increase the removal of IDL and LDL, and decrease the production of VLDL and LDL) increase in LDL receptors small
2 Heterozygous Fami lial Hypercholesterolemia in Pediatric Patients
Prescribe statins with caution to: People with history of liver disease
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101 Nicolls Road Health Sciences Center, Level 4 Stony Brook, NY 11794-8434 evidence from a small double-blind, placebo-controlled trial of 35 patients receiving atorvastatin, 10 mg daily, versus alternate day regimen showed LDL cholesterol
they are therefore useful for nondaily dosing regimens
estimate the level of risk using the QRISK2 assessment tool: NICE appraisal states that statin therapy (1): atorvastatin 20mg per day is the statin used in primary prevention
rosuvastatin and pravastatin are excreted largely unchanged
Your doctor may increase your dose as needed
59)
1,600 patients were recruited to the study - these patients were randomly allocated to receive either atorvastatin at the Hippocration Hospital in Thessaloniki, Greece, or 'usual' care outside the hospital for a mean follow-up of three years; patients receiving atorvastatin had their dose titrated until they reached target LDL-C of < 2
Use a lower dose of atorvastatin if any of the following apply: potential drug interactions Last edited 17 Feb 2022
7% and 18
Comments: Following initiation and/or upon titration, lipid levels should be evaluated within 2 to 4 weeks and dosages adjusted accordingly
A lower dose of atorvastatin if any of the following An individual patient data meta-analysis of 37 studies (n = 32,258) which assessed the extent to which high-intensity statins (rosuvastatin 20-40 mg and atorvastatin 40-80 mg) reduced LDL-C in each of four statin benefit groups, found reductions in LDL-C with rosuvastatin 20 and 40 mg were greater than with atorvastatin 40 mg overall and in Discuss the benefits of changing to high-intensity treatment with atorvastatin 80 mg (or lower if necessary) if the person is stable on a low-intensity statin (such as simvastatin 10 mg) or a medium intensity statin (such as simvastatin 20 or 40 mg)
Your doctor appears to be following the latest recommendations from the American Heart Association and the FDA
Atorvastatin — use with caution and adjust atorvastatin dose
offer atorvastatin 20 mg for the primary prevention of CVD (cardiovascular disease) to people who have a 10% or greater 10-year risk of developing CVD; secondary prevention