Second, its reported unbound fraction covers a wide range (1–61%), affecting the distribution and clearance process, and ultimately Pharmacology Indication
The basis of loading dose calculations involves a drug's volume of distribution (Vd)
Blood samples were drawn 4 and 8 hr after the last dose on 2 successive days at the end of each step and analyzed for phenytoin concentration
For phenytoin, a Vd of 0
Results: The developed phenytoincapecitabine interaction model successfully described the profiles of serum
Phenytoin is poorly soluble in water and is therefore commonly given The median (IQR) for direct-measured, routine and Sheiner–Tozer equation calculated free phenytoin concentration were 1
60–1
Pharmacokinetic equations can be used to calculate a reloading dose according to the desired goal concentration; however, the use of these equations has not been validated in critically ill populations
1002/jcph
PK, in particular, is a study of what the body does to a drug, deals with the processes of absorption, distribution, metabolism, and elimination (acronym ADME)
to complete for performing are designed to vancomycin, mathematical appropriate show the easily theophylline, understandable, consults
With an average monthly cost of $30, it has also become one of the most widely used anticonvulsants, listed on the World Health Organization’s List of Essential Medicines
57 g/dL
Phenytoin